WARNINGS 

• Do not vaccinate within 21 days before slaughter.    
• Do not use contrary to “directions for use”.
• Good management practices are recommended to reduce exposure to Marek’s Disease Virus and Newcastle Disease Virus for at least 2 weeks following vaccination.     
• Accidental self-injection may cause a local allergic reaction. If this occurs consult a physician.
• Keep out of reach of children, uninformed persons and animals.
• Although this vaccine has been extensively tested under a wide variety of conditions, failure thereof may ensue as a result of various reasons.  If this is suspected, seek veterinary advice and notify the registration holder.

PRECAUTIONS    

• Vaccinate healthy birds only.
• All the birds in the flock must be vaccinated at the same time.
• This vaccine is presented in a frozen cell associated form. The cells and virus particles are very fragile and require careful handling to prevent damage or loss of titre in order to achieve optimum efficacy.
• Do not remove vaccine from liquid nitrogen until ready for use.
• Improper storage or handling of the vaccine may result in potency loss.
• Do not re-freeze thawed vaccine.
• Do not use vaccine that has thawed in the liquid nitrogen container.
• Ensure proper dosage. Do not overdose or over dilute the vaccine.
• Observe aseptic precautions and ensure all vaccination equipment is clean and sterile prior to use.
• Use opened vaccine as quickly as possible and do not store unused vaccine for future use.
• Use appropriate safety equipment when handling liquid nitrogen containers and frozen vaccine.
• It is good vaccination practice that contact with eyes, hands and mouth be avoided while handling the vaccine.
• Destroy any unused vaccine by, for example, burning; dispose of all the vaccine containers when the vaccination is completed.
• Wash and disinfect hands after use.

DOSAGE AND DIRECTIONS FOR USE:     USE ONLY AS DIRECTED.

Carefully read the directions before use. The instructions must be completely followed.

VECTORMUNE^® HVT NDV & RISPENS must be administered by in ovo vaccination in 18 - 19 day old embryonated eggs or by subcutaneous vaccination in day old chicks.

Vaccine preparation:

Be familiar with all safety and precautionary measures for handling liquid nitrogen to prevent personal injury.

Wear gloves, face protection and protective clothing.

Check the liquid nitrogen container to confirm a sufficient amount of liquid nitrogen is present to keep the vaccine frozen. If thawed, do not use the vaccine. The containers (Dewar) must be checked regularly for liquid nitrogen level and must be refilled as needed.

After calculating the number of doses of vaccine and diluent required, quickly remove the exact amount of ampoules needed.

A maximum of 4 ampoules should be thawed at one time. After inspecting the diluents and completing all preparations, the vaccine should be quickly removed from the Dewar and placed into a water bath of 26,5 °C to thaw. This step can be repeated until the appropriate dosage has been reached.

Gentle agitation during the thawing process promotes rapid, uniform thawing and evenly distributes the vaccine in the ampoule.

Immediately after thawing, mix vaccine with diluent at room temperature.  Gently draw the vaccine from the ampoule with an 18-gauge, 1,5 inch needle and slowly mix with the diluent.  (See diluent vaccine ratio below).

Immediately use the vaccine and agitate occasionally to ensure uniform suspension of cells.

Administration of vaccine:

• 1.            For subcutaneous vaccination in day old chicks.

            Sterilize the automatic syringe, needles and other accessories by auto claving or                     boiling prior to vaccination.

            Use a short 20 gauge needle for vaccination.

            Mix 200 mℓ of diluent for each 1 000 doses of vaccine.

            Subcutaneously inject 0,2 mℓ of diluted vaccine into the back of the neck of each                   chick.

            The preferred site is under the skin on the back of the neck midway between the head             and the body and in a direction away from the head. Do not inject near the head. Do               not inject into the muscle tissue or the neck vertebrae.

• 2.            For in ovo vaccination in 18 - 19 day old chicken embryos.  

            Sanitize the egg injection system before and after use following procedures described               in operator’s manual.

            Read the egg injection system operator’s manual before initiating vaccination. Failure               to follow instructions may result in personal injury, excessive embryonic mortality and             low hatchability.

            Mix 100 mℓ of diluent  for each 1 000 doses of vaccine to administer 0,1 mℓ per                       chicken embryo or mix 50 mℓ for each 1 000 doses of vaccine to administer 0,05 mℓ                 per chicken embryo.

PRESENTATION  

2 mℓ fire sealed glass ampoules containing 1 000, 2 000 or 4 000 doses stored in liquid nitrogen.

REGISTRATION HOLDER

Ceva Animal Health (Pty) Ltd

Reg No 1973016009/07

P O Box 7707

Halfway House, 1685

RSA

Tel +27 11 312 4088

MANUFACTURER

Ceva Biomune

8906 Rosehill Road

Lenexa

Kansas 66215

USA

U.S. Vet Lic. No. 368